The Center for Clinical Genomics of Microbial Systems (CC-GEMS)

Our Mission:

The mission of the Center for Clinical Genomics of Microbial Systems (CC-GEMS) is to apply next-generation sequencing and related technologies to clinical medicine with materials from patients and/or research subjects. The Center's goal is to generate new information on pathogens, microbiomes, and host-parasite interactions that may lead to an improved understanding of host-microbial interactions and improvements in clinical care. The Center:

  • Provides the WUSM infectious disease community with access to NGS and related technologies
  • Promotes development of novel diagnostic approaches (based on NGS data) and treatments
  • Link experts in microbial genomics and metagenomics bioinformatics analysis with clinicians, microbiologists, and subject samples
  • Train clinicians and scientists in the basic principles of microbial genomics and study design

(PMC4177058) Human virome in five body habitats

Cytomegalovirus

(PMC4054670) Bacterial genera accumulation curve

Wuchereria bancrofti

(PMC4164201) Biosynthetic Gene Clusters

(PMC3573124) Drug interactions with kinase groups

(PMC4073010) Community class PCoA

Candida albicans

(PMC4151715) Bacterial class abundance over time

(PMC4054670) Shannon diversity comparison across 22 habitats
These activities enable Washington University to maintain its position as a leader in the field of Genomics of Microbial Systems; they also enable clinical, translational and basic science researchers to explore understudied aspects of infectious diseases, host-microbe interactions and variations in the human microbiome in health and disease. The Center supports basic, translational, and clinical research. CC-GEMS projects facilitate development of new therapeutics and diagnostics for infections and other microbially-driven conditions.

Upcoming Seminars:

Recent Publications:

Infectious Diseases Genomics Seminar
Friday November 17th 2017 @ 12:00pm
  
Jeffrey Henderson, MD PhD
(Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine)
Anne Robinson
(Biochemistry, Biophysics and Structural Biology Program, Washington University School of Medicine)
Virulence-associated metal ion interactions in extraintestinal pathogenic E.coli
  

Large Conference Room
Rm. 4134/4135 MGI
4444 Forest Park Blvd.

Lunch is provided
(RSVP to: ghaida@dom.wustl.edu)
Pittman JE, Wylie KM, Akers K, Storch GA, Hatch J, Quante J, Frayman KB, Clarke N, Davis M, Stick SM, Hall GL, Montgomery G, Ranganathan S, Davis SD, Ferkol TW; Australian Respiratory Early Surveillance Team for Cystic Fibrosis. Association of Antibiotics, Airway Microbiome, and Inflammation in Infants with Cystic Fibrosis. Ann Am Thorac Soc. 2017 Oct;14(10):1548-1555. doi: 10.1513/AnnalsATS.201702-121OC. PubMed PMID: 28708417.

Dorshow RB, Hall-Moore C, Shaikh N, Talcott MR, Faubion WA, Rogers TE, Shieh JJ, Debreczeny MP, Johnson JR, Dyer RB, Singh RJ, Tarr PI. Measurement of gut permeability using fluorescent tracer agent technology. Sci Rep. 2017 Sep 7;7(1):10888. doi: 10.1038/s41598-017-09971-y. PubMed PMID: 28883476; PubMed Central PMCID: PMC5589723.

Dobbs KR, Embury P, Vulule J, Odada PS, Rosa BA, Mitreva M, Kazura JW, Dent AE. Monocyte dysregulation and systemic inflammation during pediatric falciparum malaria. JCI Insight. 2017 Sep 21;2(18). pii: 95352. doi: 10.1172/jci.insight.95352. [Epub ahead of print] PubMed PMID: 28931756; PubMed Central PMCID: PMC5621919.

Ammerman E, Sweet SC, Fenchel M, Storch GA, Conrad C, Hayes D Jr, Faro A, Goldfarb S, Melicoff E, Schecter M, Visner G, Williams NM, Danziger-Isakov L. Risk and outcomes of pulmonary fungal infection after pediatric lung transplantation. Clin Transplant. 2017 Sep 4. doi: 10.1111/ctr.13100. [Epub ahead of print] PubMed PMID: 28871606.

 
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  CC-GEMS v1.0           Copyright Statement 
The Genome Institute Washington University School of Medicine, Dept. of Medicine  Washington University School of Medicine, Dept. of Pediatrics  Washington University in St. Louis